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It's also not clear whether the same hormonal effects would be seen in men taking lower doses of ibuprofen, or whether the effects are reversible, particularly in men who take ibuprofen for long periods, study co-author Bernard Jégou, director of the National Institute for Research on Environmental and Occupational Health in France, told CNN.
Still, over the short term, it's likely that these effects are reversible, Jégou said.
Separate experiments in the study using human testicular tissue in a lab dish also suggested that ibuprofen could affect testosterone production.
It's important to note that the study did not look at sperm production or other more direct indicators of the men's fertility, so further studies would be needed to examine this, the researchers said.
Men who take relatively high doses of ibuprofen may be at increased risk for fertility problems, early research suggests.
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